5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE
5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE
CAS: 171178-45-3
Molecular Formula: C10H13ClN2O2
5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE - Names and Identifiers
5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE - Physico-chemical Properties
| Molecular Formula | C10H13ClN2O2 |
| Molar Mass | 228.68 |
| Density | 1.245±0.06 g/cm3(Predicted) |
| Melting Point | 127-129°C |
| Boling Point | 283.7±25.0 °C(Predicted) |
| pKa | 12.06±0.70(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE - Risk and Safety
| HS Code | 29333990 |
| Hazard Class | IRRITANT |
5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE - Upstream Downstream Industry
| Raw Materials | 6-CHLORO-4-IODOPYRIDIN-3-AMINE CARBAMIC ACID, (6-CHLORO-4-IODO-3-PYRIDINYL)-, 1,1-DIMETHYLETHYL ESTER 5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID |
5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE - Reference Information
| Introduction | 5-(N-tert-butoxycarbonylamino) 2-chloropyridine and its derivatives are a very useful class of aminopyridine derivatives as important pharmaceutical intermediates. |
| preparation | add 200 mL of 5-amino-2-chloropyridine and buffer solution consisting of sodium carbonate and sodium bicarbonate to a three-necked flask with stirring device, in an ice bath, tert-butyl dicarbonate was added dropwise to the dropping funnel. The reaction was stirred in a water bath at 30 °c for 22 hours. The reactant was extracted with diethyl ether (100 ml× 2) to remove unreacted tert-butyl dicarbonate, and the resulting aqueous phase was adjusted to Ph 2-3 with 3mol/L aqueous hydrochloric acid, then it was extracted with ethyl acetate (100 ml× 4), dried over anhydrous sodium sulfate, filtered, and the solvent was removed by rotary evaporator, 5-(N-tert-butoxycarbonylamino)-2-chloropyridine is obtained as a colorless oil liquid. |
Last Update：2024-04-10 22:29:15
5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE - Security information
| HazardClass | IRRITANT |
| customs code | 29333990 |
Last Update：2024-04-09 01:59:49
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Product Name: tert-Butyl(6-chloropyridin-3-yl)carbamate Request for quotationCAS: 171178-45-3
Tel: 400-968-2212
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Mobile: 18916960931
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Spot supply
Product Name: tert-Butyl (6-chloropyridin-3-yl)carbamate Visit Supplier Webpage Request for quotationCAS: 171178-45-3
Tel: +86-400-900-4166
Email: product@acmec-e.com
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Multiple Specifications
Product Name: 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE Request for quotationCAS: 171178-45-3
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
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QQ: 1377812380
Product Name: 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE Visit Supplier Webpage Request for quotation
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Tel: 18301782025
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CAS: 171178-45-3
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Email: 3008007409@qq.com
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View History
Raw Materials for 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE
6-CHLORO-4-IODOPYRIDIN-3-AMINE
CARBAMIC ACID, (6-CHLORO-4-IODO-3-PYRIDINYL)-, 1,1-DIMETHYLETHYL ESTER
5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID
CARBAMIC ACID, (6-CHLORO-4-IODO-3-PYRIDINYL)-, 1,1-DIMETHYLETHYL ESTER
5-AMINO-2-CHLOROPYRIDINE-4-CARBOXYLIC ACID